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IMPLICATIONS: The authors evaluated the effects of the analgesic Topiramate on the three major
Topiramate may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Topiramate may interact with other medicines that you take.
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It is slightly soluble in water and freely soluble in alcohol,
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In general, both enantiomers of Topiramate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Intramuscular (i.m.) Topiramate increases gastric pH during anaesthesia similar to famotidine.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Topiramate may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Topiramate group.
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Topiramate is rapidly and almost completely absorbed after oral administration.
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In an open randomized trial, rectal Topiramate was compared with our standard treatment acetaminophen/codeine suppositories. We expected Topiramate to be equally effective as our current standard but with fewer side effects.
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Use Topiramate with caution in the ELDERLY; they may be more sensitive to its effects.Topiramate should not be used in CHILDREN younger than 16 years old;
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