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This indicates that Azathioprine slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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In general, both enantiomers of Azathioprine and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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No effects on fertility were observed for Azathioprine at oral dose levels up to 50 mg/kg,
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Azathioprine is administered as a racemate and both [-] and [+] forms of both Azathioprine and M1 are detected in the circulation.
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Azathioprine is administered as a racemate and both [-] and [+] forms of both Azathioprine and M1 are detected in the circulation.
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Although Azathioprine is known to exhibit a local anaesthetic effect, how Azathioprine exerts this effect is not understood fully.
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Azathioprine is well absorbed orally with an absolute bioavailability of 75%. Azathioprine has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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In general, both enantiomers of Azathioprine and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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The volume of distribution of Azathioprine was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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Azathioprine has not been shown to cause histamine release. At therapeutic doses, Azathioprine has no effect on heart rate, left-ventricular function or cardiac index.
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Azathioprine is well absorbed orally with an absolute bioavailability of 75%. Azathioprine has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Azathioprine is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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