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IMPLICATIONS: The authors evaluated the effects of the analgesic Topamax on the three major
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Topamax should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Topamax has not been shown to cause histamine release. At therapeutic doses, Topamax has no effect on heart rate, left-ventricular function or cardiac index.
Topamax is associated with craving and tolerance development.
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Topamax was evaluated in peri- and post-natal studies in rats.
If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Topamax while you are pregnant.
Topamax may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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Nonetheless, Topamax nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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Topamax can impair thinking and the physical abilities required for driving or operating machinery. Topamax should be avoided in patients intoxicated with alcohol,
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Topamax has been shown to cause harm to the fetus.
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The analgesic activity of Topamax is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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