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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Zomax is rapidly and almost completely absorbed after oral administration.
If you think you or someone else may have taken an overdose of Zomax,
Use Zomax with caution in the ELDERLY; they may be more sensitive to its effects.Zomax should not be used in CHILDREN younger than 16 years old;
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A single i.m. dose of Zomax is useful pre-treatment to minimize the risk of acid aspiration during operation,
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No effects on fertility were observed for Zomax at oral dose levels up to 50 mg/kg,
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Zomax is well absorbed orally with an absolute bioavailability of 75%. Zomax has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Zomax and M1 elimination half-lives (13 hrs. for Zomax and 19 hrs. for M1).
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This is known as physical DEPENDENCE. If you suddenly stop taking Zomax , you may experience WITHDRAWAL symptoms including anxiety;
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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In vitro studies indicate that Zomax is unlikely to inhibit,
Zomax is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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These mechanisms may contribute independently to the overall analgesic profile of Zomax.
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We investigated the antacid analgesic value of a single dose of i.m. Zomax given 1 h before elective ,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Zomax is rapidly and almost completely absorbed after oral administration.
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The analgesic activity of Zomax is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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These mechanisms may contribute independently to the overall analgesic profile of Zomax.
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Nonetheless, Zomax nearly doubled the interthreshold range at a concentration near 200 ng/mL.
Zomax is administered as a racemate and both [-] and [+] forms of both Zomax and M1 are detected in the circulation.
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Zomax can impair thinking and the physical abilities required for driving or operating machinery. Zomax should be avoided in patients intoxicated with alcohol,
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Some people who use Zomax for a long time without a break may develop a physical need to continue taking it.
A single i.m. dose of Zomax is useful pre-treatment to minimize the risk of acid aspiration during operation,
We expected Zomax to be equally effective as our current standard.
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