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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Zyrtec and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Zyrtec has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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The effects of Zyrtec are similar to those of narcotic analgesics. Although Zyrtec is not classified as a narcotic, it may become habit-forming,
causing mental or physical dependence.It works in certain areas of the brain and nervous system to decrease pain.
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Zyrtec and M1 elimination half-lives (13 hrs. for Zyrtec and 19 hrs. for M1).
Talk with your doctor if Zyrtec stops working well. Do not take more than prescribed.Some people who use Zyrtec for a long time without a break may develop a physical need to continue taking it.
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Zyrtec is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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It is slightly soluble in water and freely soluble in alcohol,
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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If you suddenly stop taking Zyrtec , you may experience WITHDRAWAL symptoms including anxiety;
You may not be able to take Zyrtec, or you may require a dosage adjustment,
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In general, both enantiomers of Zyrtec and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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The analgesic activity of Zyrtec is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Zyrtec has been shown to cause harm to the fetus.
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Zyrtec can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
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Racemic Zyrtec is rapidly and almost completely absorbed after oral administration.
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Intramuscular (i.m.) Zyrtec increases gastric pH during anaesthesia similar to famotidine.
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