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For Imuran, the following should be considered:The suitability of Imuran suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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Imuran can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,

Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Imuran is rapidly and almost completely absorbed after oral administration.
Imuran should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Imuran has both opioid and monoaminergic agonist actions.
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The analgesic activity of Imuran is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Imuran is well absorbed orally with an absolute bioavailability of 75%. Imuran has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Imuran has not been shown to cause histamine release. At therapeutic doses, Imuran has no effect on heart rate, left-ventricular function or cardiac index.
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Imuran is well absorbed orally with an absolute bioavailability of 75%. Imuran has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Imuran is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Forty patients were treated with either Imuran suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Imuran increases the risk of CNS and respiratory depression in these patients.
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the rates of withdrawals due to adverse events appeared to be higher in the Imuran groups.
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These effects may be worse if you take it with alcohol or certain medicines. Use Imuran with caution.
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This indicates that Imuran slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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Imuran is administered as a racemate and both [-] and [+] forms of both Imuran and M1 are detected in the circulation.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Imuran and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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