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Methotrexate is well absorbed orally with an absolute bioavailability of 75%. Methotrexate has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Methotrexate is administered as a racemate and both [-] and [+] forms of both Methotrexate and M1 are detected in the circulation.
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