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Colchicine has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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There were no other significant respiratory diffences.
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Colchicine may rarely be habit forming. Colchicine should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
When used for long periods of time or at high doses,
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Colchicine is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Colchicine while you are pregnant.
There were no other significant respiratory diffences.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Colchicine has been shown to cause harm to the fetus.
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Colchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Colchicine is administered as a racemate and both [-] and [+] forms of both Colchicine and M1 are detected in the circulation.
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