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Tacrolimus and M1 elimination half-lives (13 hrs. for Tacrolimus and 19 hrs. for M1).
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Tacrolimus may not work as well and may require higher doses to obtain the same effect as when originally taken.
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Tacrolimus ; it may add to their effects.
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Tacrolimus is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Tacrolimus may rarely be habit forming. Tacrolimus should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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