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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Sinemet is rapidly and almost completely absorbed after oral administration.
Sinemet was not mutagenic in the following assays:
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Other medicines�Although certain medicines should not be used together at all,
since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.

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In general, both enantiomers of Sinemet and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.



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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Sinemet and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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