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    In general, both enantiomers of Stavudine and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
    Stavudine was not mutagenic in the following assays: Ames Salmonella microsomal activation test,

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    Stavudine has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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    This may not be a complete list of all interactions that may occur. Ask your health care provider if Stavudine may interact with other medicines that you take.
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    causing mental or physical dependence.It works in certain areas of the brain and nervous system to decrease pain.
    The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Stavudine and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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    In an open randomized trial, rectal Stavudine was compared with our standard treatment acetaminophen/codeine suppositories. We expected Stavudine to be equally effective as our current standard but with fewer side effects.
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