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Nonetheless, Sinequan nearly doubled the interthreshold range at a concentration near 200 ng/mL.
In general, both enantiomers of Sinequan and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Sinequan increases the risk of CNS and respiratory depression in these patients.
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Forty patients were treated with either Sinequan suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Sinequan was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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Sinequan had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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Sinequan has both opioid and monoaminergic agonist actions.
Sinequan may rarely be habit forming. Sinequan should be avoided in patients with a history.
Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Sinequan is rapidly and almost completely absorbed after oral administration.
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Sinequan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Sinequan is a centrally acting synthetic opioid analgesic.
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This indicates that Sinequan slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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Sinequan may rarely be habit forming. Sinequan should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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Although Sinequan is known to exhibit a local anaesthetic effect, how Sinequan exerts this effect is not understood fully.
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In an open randomized trial, rectal Sinequan was compared with our standard treatment acetaminophen/codeine suppositories. We expected Sinequan to be equally effective as our current standard but with fewer side effects.
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This indicates that Sinequan slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
The volume of distribution of Sinequan was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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These mechanisms may contribute independently to the overall analgesic profile of Sinequan.
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