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Clonidine may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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The analgesic activity of Clonidine is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Clonidine and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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