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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Suminat ; it may add to their effects.
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Suminat and M1 elimination half-lives (13 hrs. for Suminat and 19 hrs. for M1).
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There were no other significant respiratory diffences.
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Respiratory depression should be treated as an overdose.
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The 6-hour TOTPAR scores for the Suminat groups and ASA/,
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Suminat has not been shown to cause histamine release. At therapeutic doses, Suminat has no effect on heart rate, left-ventricular function or cardiac index.
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Suminat is a centrally acting synthetic opioid analgesic.
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Suminat has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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patients receiving Suminat had a median gastric fluid pH of 6.4,
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Suminat may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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more potent than Suminat in producing analgesia and 200 times more potent in ?-opioid binding.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Suminat and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Suminat and M1, respectively.
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