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If you suddenly stop taking Emsam , you may experience WITHDRAWAL symptoms including anxiety;
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No effects on fertility were observed for Emsam at oral dose levels up to 50 mg/kg,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Emsam is rapidly and almost completely absorbed after oral administration.
Nonetheless, Emsam nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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We expected Emsam to be equally effective as our current standard.
In an open randomized trial, rectal Emsam was compared with our standard treatment acetaminophen/codeine suppositories. We expected Emsam to be equally effective as our current standard but with fewer side effects.
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The effects of Emsam are similar to those of narcotic analgesics. Although Emsam is not classified as a narcotic, it may become habit-forming,
Emsam is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Nonetheless, Emsam nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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The binding of Emsam to human plasma proteins is approximately 20%,
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Emsam was not mutagenic in the following assays:
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Although Emsam is known to exhibit a local anaesthetic effect, how Emsam exerts this effect is not understood fully.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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A single i.m. dose of Emsam is useful pre-treatment to minimize the risk of acid aspiration during operation,
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Emsam group.
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Intramuscular (i.m.) Emsam increases gastric pH during anaesthesia similar to famotidine.
There were no other significant respiratory diffences.
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