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Methotrexate may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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This is known as physical DEPENDENCE. If you suddenly stop taking Methotrexate , you may experience WITHDRAWAL symptoms including anxiety;
It is slightly soluble in water and freely soluble in alcohol,
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Methotrexate and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Methotrexate and M1, respectively.
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In general, both enantiomers of Methotrexate and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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