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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Mercaptopurine and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Mercaptopurine and M1 elimination half-lives (13 hrs. for Mercaptopurine and 19 hrs. for M1).
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Mercaptopurine may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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