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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Emsam is rapidly and almost completely absorbed after oral administration.
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The suitability of Emsam suppositories for inclusion in our hospital formulary,
Forty patients were treated with either Emsam suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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It is slightly soluble in water and freely soluble in alcohol,
Emsam and M1 elimination half-lives (13 hrs. for Emsam and 19 hrs. for M1).
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Emsam has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Forty patients were treated with either Emsam suppositories 100 mg 6 hourly.
The product information for Emsam states that convulsions have been reported in patients using Emsam at the recommended dose levels and that the risk
There were no other significant respiratory diffences.
It is slightly soluble in water and freely soluble in alcohol,
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For Emsam, the following should be considered:The suitability of Emsam suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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