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In an open randomized trial, rectal Loxitane was compared with our standard treatment acetaminophen/codeine suppositories. We expected Loxitane to be equally effective as our current standard but with fewer side effects.
The volume of distribution of Loxitane was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
Loxitane is a centrally acting synthetic opioid analgesic.
clinical trial was performed to assess the analgesic efficacy and reported side effects of Loxitane 100 mg, Loxitane 50 mg,
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Loxitane is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Loxitane may rarely be habit forming. Loxitane should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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more potent than Loxitane in producing analgesia and 200 times more potent in ?-opioid binding.
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Loxitane was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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Loxitane is well absorbed orally with an absolute bioavailability of 75%. Loxitane has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Respiratory depression should be treated as an overdose.
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patients receiving Loxitane had a median gastric fluid pH of 6.4,
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For Loxitane, the following should be considered:The suitability of Loxitane suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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Loxitane has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
The suitability of Loxitane suppositories for inclusion in our hospital formulary,
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