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Renova is associated with craving and tolerance development.
Renova is well absorbed orally with an absolute bioavailability of 75%. Renova has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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the rates of withdrawals due to adverse events appeared to be higher in the Renova groups.
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Renova is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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The analgesic activity of Renova is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Renova was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Renova ; it may add to their effects.
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The binding of Renova to human plasma proteins is approximately 20%,
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In an open randomized trial, rectal Renova was compared with our standard treatment acetaminophen/codeine suppositories. We expected Renova to be equally effective as our current standard but with fewer side effects.
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Renova may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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Renova is administered as a racemate and both [-] and [+] forms of both Renova and M1 are detected in the circulation.
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Renova 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,
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The low numbers they quoted on Renova addiction and detoxification seem paltry in comparison
In general, both enantiomers of Renova and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Renova may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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