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Use Tizanidine with caution in the ELDERLY; they may be more sensitive to its effects.Tizanidine should not be used in CHILDREN younger than 16 years old;
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Tizanidine is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
more potent than Tizanidine in producing analgesia and 200 times more potent in ?-opioid binding.
the manufacturer-sponsored surveillance program's estimated rates of Tizanidine abuse in a Tizanidine-exposed population.
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We investigated the antacid analgesic value of a single dose of i.m. Tizanidine given 1 h before elective ,

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Tizanidine has not been shown to cause histamine release. At therapeutic doses, Tizanidine has no effect on heart rate,
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Tizanidine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Although Tizanidine is known to exhibit a local anaesthetic effect, how Tizanidine exerts this effect is not understood fully.
there is a growing concern about Tizanidine addiction.
Breast-feeding�Tizanidine passes into breast milk and may cause unwanted effects in nursing babies.
In general, both enantiomers of Tizanidine and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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The analgesic activity of Tizanidine is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Tizanidine and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Tizanidine and M1, respectively.
Tell your doctor or dentist that you take Tizanidine before you receive any medical or dental care, emergency care, or surgery.
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