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Doxil had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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In general, both enantiomers of Doxil and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
The binding of Doxil to human plasma proteins is approximately 20%,
Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Doxil is rapidly and almost completely absorbed after oral administration.
Doxil is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Doxil may interact with other medicines that you take.
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Doxil is a centrally acting synthetic opioid analgesic.

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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Doxil and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Doxil and M1, respectively.
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Doxil has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,



Intramuscular (i.m.) Doxil increases gastric pH during anaesthesia similar to famotidine.
Doxil can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,

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How does Doxil work? What will it do for me?Doxil can cause side effects that may impair your thinking or reactions.
Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Doxil while you are pregnant.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
Do not use this medication if you are allergic,
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