Synephrine (5985-28-4) is an alkaloid that is commonly used to form the supplement Synephrine HCL. This article includes the Synephrine facts, Synephrine history, synephrine HCL mechanism of action, health benefits of synephrine, potential side effects/risks of synephrine and synephrine recommended usage.

Synephrine History

The use of Synephrine (Cas: 5985-28-4, known as para Synephrine, or p-Synephrine) dates back to many years ago and can be traced back to the native China. The medicinal value of Synephrine was discovered in the region where it first used to treat gastrointestinal ailments such as nausea and constipation. Also, the ancient Brazilians used Synephrine as a remedy to sleeplessness, anxiety and convulsions.raw Synephrine powder
The following are some of the common facts that everyone who intends to use Synephrine should know about the fruit from which the chemical is derived from(bitter orange fruit) :

The fruit also contains other chemicals among them being ephedrine. The concentration of the latter substance is however very little.
Bitter orange fruit has been in existence for long and its use stems back to native Asia where it was mainly used to treat stomach complications. It is also highly available in parts of Eastern Africa.
Traditionally, bitter orange was used to treat nausea, constipation, and indigestion. In the Mediterranean, it was used to treat heartburn, promote weight loss and decrease appetite. Its oil extracts were sometimes applied to the skin, but it has mostly been used in its extract form.
Synephrine powder has for long been confused for other substances that are similar to it. This confusion has been so serious that even some reputable scientific journals find it difficult to establish where to classify this chemical appropriately. Some of the substances that are similar but yet different from Synephrine include the following:

Bitter orange extract. This is primarily the source of Synephrine. However, many people are still not aware that other than this chemical, there exist other substances in the extract that are similar to Synephrine yet very different in terms of their modes of action. For this reason, the bitter orange is known as a reliable solution for the treatment of various diseases and the chemicals responsible for the treatment of these ailments are different from p-Synephrine.
Phenylephrine. This chemical is structurally very similar to Synephrine, but their modes of action are ways apart. While Synephrine is used for improving the body’s metabolism through thermogenesis, phenylephrine is primarily used as a nasal decongestant. The chemical phenylephrine is also used in surgical operations to dilate the eye’s pupil during an operation. Phenylephrine is made synthetically. On the other hand, Synephrine, is obtained from plant extracts.
Ephedrine. The bitter orange fruit has also been found to have significant reserves of this Ephedrine. Ephedrine is a very strong stimulant and whose use must be controlled as it is strongly addictive.
The structure of the stimulant ephedrine is similar to that of Synephrine, and this is primarily the confusing bit of the two chemicals. However, the use of ephedrine is prohibited in many places for its adverse effects to humans, especially if you take Synephrine without control. On the other hand, use of Synephrine doesn’t carry any similar side effects, and it is thus considered to be a safer option as compared to ephedrine.