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Testis Development and Germ Cell Differentiation Group
Sperm, and the processes by which they develop, are of fundamental importance human health and wellbeing because sperm transmit all paternal genetic and epigenetic information to the next generation. By investigating how these cells form and function, our research program addresses the burdens of male infertility (affecting 1 in 20 couples) and testicular cancer (rising at 2% per annum; the most common solid cancer for men aged 19 43 years)Our discoveries have included defining molecular and cellular signalling switches that mediate normal testis development for full fertility and that can lead to infertility when impaired. Such knowledge is essential for improved prevention and therapies for men experiencing fertility problems and for their offspring who may also be affected by these burdens or their consequencesTo find specific factors and the windows of vulnerability important for human male fertility, our research program examines events spanning from fetal life, when the testis first forms, through to adulthood. We have learned that certain cellular growth signals are used at specific ages to enable correct growth of the testis, creating the foundation for fertility in adulthood. Our observations have shown how differences in gene dosage can change the pace of testis development, leading to early puberty in an otherwise healthy individualTesticular cancer arising from male germ cell (sperm precursor) tumours is one of the most common forms of cancer for young men aged 25 39. Treatment for this disease has a high degree of success, but there is much to be learned about why the incidence of this cancer continues to increase worldwide. Early detection and prevention may lead to fertility sparing treatments, and these are key motivators for understanding how it develops. We have shown that cellular signalling molecules that guide normal events in fetal life may be disrupted in the testes of men who suffer from this conditionIn the Loveland laboratory, our objective is to define key switches that guide sperm cell development in the healthy testis and during disease. We primarily use mouse and human testis cell lines and tissue explants alongside with genetically modified mouse models. Our important collaborators provide access to other relevant models such as Drosophila (fruit flies), colon cancer and malaria that extend the relevance of our discoveries to many areas of biomedical importanceThe lab is headed by Professor Kate Loveland who supervises a team of Research Fellows, Research Assistants and students undertaking Honours, Masters and PhD training. Our lab is all about research, but research needs fuel, and what better fuel than lab members who bake yummy food, a lab head that brings back food from wherever the last conference was, and group of scientists who encourage each other in every way!
Collaborators (possible co supervisors): Dr. Helen Abud, Dr. Julia Young, Dr. Patrick Western
Activin, Hedgehogs and Wnts all contribute to the milieu of growth factors that drive normal testis development and are essential for normal fertility in males. Projects examining each of these will address how crosstalk between the germ cells and their knock off van cleef turquoise alhambra necklace supporting somatic cells control spermatogenic progression during development and in adult life using mouse models complemented with organ and cell cultures. We also examine how these signalling pathways may contribute to testicular cancer and infertilityImmune cells in testis development: Their profiles and control by activin signalling
Supervisor: Prof Kate Loveland
Collaborators: (possible co supervisors): Assoc Professor Mark Hedger, Dr. Nicolas Da Silva, Prof Paul McMenamin
Immune cells produce many factors known to influence cellular development, but their contribution to testis development is relatively unexplored. This project will determine the profile of immune cell development in the mouse and examine immune cells in the normal and diseased human testis, to ascertain their likely points of influence of the developmental switches required for full fertility. Yoichi Miyamoto, Dr. Julia Young
Cell differentiation requires the synthesis of a new set of proteins to perform the distinct functions of the newly differentiated cell. During van cleef heart necklace imitation these transitions, transcription factors and nuclear proteins are transported into the nucleus by importins, where they alter gene transcription and nuclear architecture. We have documented changes in the synthesis of the importins during spermatogenesis. These experiments will define how specificity of pathway activity during testis development and in spermatogenesis is limited through shared receptors (interactome) or overlapping signaling components (Loveland et al., 2007), such as the shared use of Smad2/3 by activins, nodal and TGF In contrast, BMPs typically act via Smad1/5/8 which transiently can also be used by TGF and their local activity will influence activin and nodal signalling outcomesHuman testis cancer control by local factors; interrogation of Hedgehog and activin signalling pathways and immune cells
To define the key immune cells in testicular cancer knock off van cleef arpels butterfly necklace and delineate the signalling pathways regulating their function, this project will be undertaken collaboration with colleagues at the Justus Liebig University in Giessen, Germany and at the University of Copenhagen in Denmark. The changing profile of activin receptor subunits and signalling modulators during testis development and in testicular cancer implicate altered activin bioactivity as a key feature of testis cancer development. Germ cell tumours also exhibit evidence of active Hedgehog signalling. Inflammatory cells are common inside and around sites of developing of established testiscular tumour, and this project will investigate the contrition of the Hedgehog (Hh) and activin signaling pathways and disturbances thereof in testicular growth and activation of specific T cell responsesDr. Kristian Almstrup, University of Copenhagen, Denmark
Sperm, and the processes by which they develop, are of fundamental importance human health and wellbeing because sperm transmit all paternal genetic and epigenetic information to the next generation. By investigating how these cells form and function, our research program addresses the burdens of male infertility (affecting 1 in 20 couples) and testicular cancer (rising at 2% per annum; the most common solid cancer for men aged 19 43 years)Our discoveries have included defining molecular and cellular signalling switches that mediate normal testis development for full fertility and that can lead to infertility when impaired. Such knowledge is essential for improved prevention and therapies for men experiencing fertility problems and for their offspring who may also be affected by these burdens or their consequencesTo find specific factors and the windows of vulnerability important for human male fertility, our research program examines events spanning from fetal life, when the testis first forms, through to adulthood. We have learned that certain cellular growth signals are used at specific ages to enable correct growth of the testis, creating the foundation for fertility in adulthood. Our observations have shown how differences in gene dosage can change the pace of testis development, leading to early puberty in an otherwise healthy individualTesticular cancer arising from male germ cell (sperm precursor) tumours is one of the most common forms of cancer for young men aged 25 39. Treatment for this disease has a high degree of success, but there is much to be learned about why the incidence of this cancer continues to increase worldwide. Early detection and prevention may lead to fertility sparing treatments, and these are key motivators for understanding how it develops. We have shown that cellular signalling molecules that guide normal events in fetal life may be disrupted in the testes of men who suffer from this conditionIn the Loveland laboratory, our objective is to define key switches that guide sperm cell development in the healthy testis and during disease. We primarily use mouse and human testis cell lines and tissue explants alongside with genetically modified mouse models. Our important collaborators provide access to other relevant models such as Drosophila (fruit flies), colon cancer and malaria that extend the relevance of our discoveries to many areas of biomedical importanceThe lab is headed by Professor Kate Loveland who supervises a team of Research Fellows, Research Assistants and students undertaking Honours, Masters and PhD training. Our lab is all about research, but research needs fuel, and what better fuel than lab members who bake yummy food, a lab head that brings back food from wherever the last conference was, and group of scientists who encourage each other in every way!
Collaborators (possible co supervisors): Dr. Helen Abud, Dr. Julia Young, Dr. Patrick Western
Activin, Hedgehogs and Wnts all contribute to the milieu of growth factors that drive normal testis development and are essential for normal fertility in males. Projects examining each of these will address how crosstalk between the germ cells and their knock off van cleef turquoise alhambra necklace supporting somatic cells control spermatogenic progression during development and in adult life using mouse models complemented with organ and cell cultures. We also examine how these signalling pathways may contribute to testicular cancer and infertilityImmune cells in testis development: Their profiles and control by activin signalling
Supervisor: Prof Kate Loveland
Collaborators: (possible co supervisors): Assoc Professor Mark Hedger, Dr. Nicolas Da Silva, Prof Paul McMenamin
Immune cells produce many factors known to influence cellular development, but their contribution to testis development is relatively unexplored. This project will determine the profile of immune cell development in the mouse and examine immune cells in the normal and diseased human testis, to ascertain their likely points of influence of the developmental switches required for full fertility. Yoichi Miyamoto, Dr. Julia Young
Cell differentiation requires the synthesis of a new set of proteins to perform the distinct functions of the newly differentiated cell. During van cleef heart necklace imitation these transitions, transcription factors and nuclear proteins are transported into the nucleus by importins, where they alter gene transcription and nuclear architecture. We have documented changes in the synthesis of the importins during spermatogenesis. These experiments will define how specificity of pathway activity during testis development and in spermatogenesis is limited through shared receptors (interactome) or overlapping signaling components (Loveland et al., 2007), such as the shared use of Smad2/3 by activins, nodal and TGF In contrast, BMPs typically act via Smad1/5/8 which transiently can also be used by TGF and their local activity will influence activin and nodal signalling outcomesHuman testis cancer control by local factors; interrogation of Hedgehog and activin signalling pathways and immune cells
To define the key immune cells in testicular cancer knock off van cleef arpels butterfly necklace and delineate the signalling pathways regulating their function, this project will be undertaken collaboration with colleagues at the Justus Liebig University in Giessen, Germany and at the University of Copenhagen in Denmark. The changing profile of activin receptor subunits and signalling modulators during testis development and in testicular cancer implicate altered activin bioactivity as a key feature of testis cancer development. Germ cell tumours also exhibit evidence of active Hedgehog signalling. Inflammatory cells are common inside and around sites of developing of established testiscular tumour, and this project will investigate the contrition of the Hedgehog (Hh) and activin signaling pathways and disturbances thereof in testicular growth and activation of specific T cell responsesDr. Kristian Almstrup, University of Copenhagen, Denmark
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