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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Bupropion group.
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The volume of distribution of Bupropion was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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These mechanisms may contribute independently to the overall analgesic profile of Bupropion.
Bupropion is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
In general, both enantiomers of Bupropion and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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If you suddenly stop taking Bupropion , you may experience WITHDRAWAL symptoms including anxiety;
Use Bupropion with caution in the ELDERLY; they may be more sensitive to its effects.Bupropion should not be used in CHILDREN younger than 16 years old;
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Bupropion can impair thinking and the physical abilities required for driving or operating machinery. Bupropion should be avoided in patients intoxicated with alcohol,
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The analgesic activity of Bupropion is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
Bupropion may rarely be habit forming. Bupropion should be avoided in patients with a history.
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Although Bupropion is known to exhibit a local anaesthetic effect, how Bupropion exerts this effect is not understood fully.
Bupropion and M1 elimination half-lives (13 hrs. for Bupropion and 19 hrs. for M1).
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If you suddenly stop taking Bupropion , you may experience WITHDRAWAL symptoms including anxiety;
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Bupropion may interact with other medicines that you take.
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