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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Hydroxyurea and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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Hydroxyurea may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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Respiratory depression should be treated as an overdose.
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When used for long periods of time or at high doses,
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Hydroxyurea may rarely be habit forming. Hydroxyurea should be avoided in patients with a history.
muscle relaxers) while you are using Hydroxyurea ; it may add to their effects.

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Forty patients were treated with either Hydroxyurea suppositories 100 mg 6 hourly.
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hydroxyurea ; it may add to their effects.
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clinical trial was performed to assess the analgesic efficacy and reported side effects of Hydroxyurea 100 mg, Hydroxyurea 50 mg,
than your doctor tells you to.Despite not being labeled habit-forming,
If you suddenly stop taking Hydroxyurea , you may experience WITHDRAWAL symptoms including anxiety;
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It is slightly soluble in water and freely soluble in alcohol,
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patients receiving Hydroxyurea had a median gastric fluid pH of 6.4,
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Forty patients were treated with either Hydroxyurea suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Hydroxyurea may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
Breast-feeding�Hydroxyurea passes into breast milk and may cause unwanted effects in nursing babies.
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Respiratory depression should be treated as an overdose.
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Prepare for the withdrawal symptoms of discontinued Hydroxyurea use.
Intramuscular (i.m.) Hydroxyurea increases gastric pH during anaesthesia similar to famotidine.
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Hydroxyurea has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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The effects of Hydroxyurea are similar to those of narcotic analgesics. Although Hydroxyurea is not classified as a narcotic, it may become habit-forming,
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To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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Hydroxyurea has not been shown to cause histamine release. At therapeutic doses, Hydroxyurea has no effect on heart rate, left-ventricular function or cardiac index.
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