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Diets high in protein, fat, or calories may lower how well your body absorbs this medicine; tell your doctor if you have a diet like this or if you will be changing your diet. Talk with your doctor. Do not stop taking Sinemet all of a sudden or lower your dose without calling your doctor. Side effects may happen. Talk with your doctor. Take even during sign-free periods. Keep a diary of your signs. Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well. Take Sinemet at the same time of day. To gain the most benefit, do not miss doses. What do I do if I miss a dose? Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from SINEMET tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.
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Diets high in protein, fat, or calories may lower how well your body absorbs this medicine; tell your doctor if you have a diet like this or if you will be changing your diet. Talk with your doctor. Do not stop taking Sinemet all of a sudden or lower your dose without calling your doctor. Side effects may happen. Talk with your doctor. Take even during sign-free periods. Keep a diary of your signs. Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well. Take Sinemet at the same time of day. To gain the most benefit, do not miss doses. What do I do if I miss a dose? Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. When carbidopa and levodopa are administered together, the half-life of levodopa is increased to about 1.5 hours. At steady state, the bioavailability of carbidopa from SINEMET tablets is approximately 99% relative to the concomitant administration of carbidopa and levodopa.

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